Water → HCID 136262690, compound

Participants

Reaction Steps

To a suspension of 2-[4-(1-hydroxy-1-methyl-ethyl)-phenyl]-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one (53.9 mg, 0.20 mmol) in ethane-1,2-diol (0.7 ml) is added toluene-4-sulfonic acid monohydrate (3.8 mg, 20 μmol). The reaction mixture is stirred for 7 days at ambient temperature. Water is added to the reaction mixture. The resulting precipitate is filtered off, washed with water and dried under vacuum. It is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent to afford 2-{4-[1-(2-hydroxy-ethoxy)-1-methyl-ethyl]-phenyl}-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one as white crystals; HPLC/MS 2.18 min (B), [M+H] 314;

Provenance & Evidence