反应详情

The title compound was synthesized from N-isopropyl-6-ethynylpyridazin-3-amine and 4-chloro-3-iodo-N-(4-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide in a manner similar to that described for in Example 1. The product was obtained as a pale yellow solid. Mp:133-135° C.; 1H NMR (300 MHz, CDCl3) δ: 10.46 (1 H, s), 8.40 (1 H, s), 8.28-8.31 (1 H, d, J=8.1 Hz), 8.04 (1 H, s), 7.82-7.84 (1 H, d, J=8.1 Hz), 7.53 (1 H, s), 7.41-7.43 (1 H, d, J=8.4 Hz), 7.34-7.36 (2 H, m), 6.81 (1 H, s), 6.66-6.69 (1 H, d, J=9.3 Hz), 5.13-5.15 (1 H, d, J=6.3 Hz), 4.08 (1 H, m), 2.29 (3 H, s), 1.30-1.32 (6 H, d, J=6.0 Hz). HRMS (ESI-TOF+): m/z [M+H]+ calcd for C27H23ClF3N6O: 539.1568. found: 539.1592.

1. customThe product was obtained as a pale yellow solid