HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 67127147, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate | HCID 66713127 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 67127147 | HCID 67127147 | — |
Reaction Steps
A mixture of EXAMPLE 3H (20.5 g) and piperazine (37.0 g) in dimethylsulfoxide (200 mL) was heated to 110° C. for 24 hours, and the mixture was allowed to cool to room temperature. The mixture was poured into water (1 L), extracted three times with dichloromethane, and the combined extracts were washed with 2× water, and brine and filtered and concentrated to give the pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174982B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-267c6c0cca2e48d9b8482a04a55fcdb3 |
| Source note | uspto-grants-2015_11 |