HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706899Generated: October 30, 2026
Benzyl Alcohol → (1R,3S)-1-(Boc-amino)-3-(Cbz-amino)cyclopentane
https://huagongshe.com/reaction/706899
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | (1S,3R)-3-(((tert-butoxy)carbonyl)amino)cyclopentane-1-carboxylic acid | HCID 1512529 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (1R,3S)-1-(Boc-amino)-3-(Cbz-amino)cyclopentane | HCID 69244770 | — |
Reaction Steps
(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid (1.03 g), diphenylphosphoryl azide (DPPA, 1.00 mL), triethylamine (0.929 mL), and benzyl alcohol (0.931 mL) were combined in toluene (10 mL) and stirred at 100° C. for 24 hours. The solution was cooled and chromatographed on silica gel using 10% ethyl acetate/hexanes to give the pure product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09174982B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-8109c859107b446bae7f313f33f1db1d |
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| Source note | uspto-grants-2015_11 |
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