Acetyl chloride → HCID 53256068, compound

HRID 706929Notes

Reaction equation

[NH:1]1[CH2:6]CC[CH:3]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:2]1.[C:16](Cl)(=[O:18])[CH3:17].CS(Cl)(=O)=O>>[C:16]([N:1]1[CH2:2][CH2:3][C@@H:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6]1)(=[O:18])[CH3:17]

Participants

Reactant 3

HCID 6367Acetyl chloride

HCID 31297Methanesulfonyl chloride

HCID 2756030tert-butyl N-[(piperidin-3-yl)methyl]carbamate

Product 1

HCID 53256068HCID 53256068, compound

Procedure

The title compound was prepared by substituting (R)-tert-butyl pyrrolidin-3-ylcarbamate for tert-butyl piperidin-3-ylmethylcarbamate and acetyl chloride for methanesulfonyl chloride in EXAMPLE 147A.

Sources & evidence

ORD record: ord-29601332137f498883fc2f0f4dc3655b
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09174982B2

Reaction notes

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