(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 86648180, compound

HRID 706937Notes

Reaction equation

HRID 706937 reaction equation
[F:1][CH:2](F)[CH2:3]I.[NH:6]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH2:7]1.N1CC[C@@H](NC(=O)OC(C)(C)C)C1>>[F:1][CH2:2][CH2:3][N:6]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:18])[O:13][C:14]([CH3:16])([CH3:15])[CH3:17])[CH2:7]1

Participants

4

Reactant 3

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 38335651,1-Difluoro-2-iodoethane

Product 1

HCID 86648180HCID 86648180, compound

Procedure

The title compound was prepared by substituting 1-fluoro-2-iodoethane for 1,1-difluoro-2-iodoethane and (S)-tert-butyl pyrrolidin-3-ylcarbamate for (R)-tert-butyl pyrrolidin-3-ylcarbamate in EXAMPLE 180A.

Sources & evidence

ORD record
ord-77fcf854ff804550bd6e65ab5ca0076f
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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