Diisopropylethylamine → HCID 87279747, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-Amino-1-Boc-piperidine	HCID 1268291	—
Reactant	HCID 56591275	HCID 56591275	—
Solvent	Ethyl Acetate	HCID 8857	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 87279747	HCID 87279747	—

Reaction Conditions

Temperature	120 °C

Reaction Steps

To a solution of EXAMPLE 82 (800 mg) and tert-butyl 4-aminopiperidine-1-carboxylate (203 mg) in dioxane (10 mL) was added Hunig's Base (1 mL). The mixture was stirred at 120° C. overnight. The mixture was diluted with ethyl acetate (200 mL) and washed with water, brine and dried over Na2SO4. After filtration and evaporation of solvent, the residue was loaded on a silica gel cartridge and eluted with 3% methanol in dichloromethane to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09174982B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-f0d75378a7e44a39a0694ad1e835c6b5
Source note	uspto-grants-2015_11