HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 706959Generated: October 30, 2026
Diisopropylethylamine → HCID 87279450, compound
https://huagongshe.com/reaction/706959
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | Potassium ethanethioate | HCID 23670855 | — |
| Reactant | HCID 87279543 | HCID 87279543 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 87279450 | HCID 87279450 | — |
Reaction Steps
To a solution of EXAMPLE 233C (456 mg) and potassium ethanethioate (197 mg) in dioxane (4 mL) was added tris(dibenzylideneacetone)dipalladium(0) (27 mg) and xantphos (33 mg) followed by N,N-diisopropylethylamine (0.5 mL). The mixture was purged with argon, sealed and stirred under microwave irradiation for 60 minutes at 120° C. The mixture was dissolved in ethyl acetate (300 mL) and water (100 mL). The organic phase was washed with brine and dried over Na2SO4. Filtration and evaporation of the solvent followed by flash chromatography (20% ethyl acetate in hexane) provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09174982B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-50bc3a21ddc640668f3446ae8a5efdfd |
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| Source note | uspto-grants-2015_11 |
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