(Oxan-4-yl)methanol → 5-bromo-6-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)pyridine-3-sulfonamide

HRID 706963Notes

Reaction equation

HRID 706963 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][OH:8])[CH2:3][CH2:2]1.[Br:9][C:10]1[CH:11]=[C:12]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:13]=[N:14][C:15]=1Cl.[F:21]C1C=CC(S(N)(=O)=O)=CC=1[N+]([O-])=O>>[Br:9][C:10]1[CH:11]=[C:12]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:13]=[N:14][C:15]=1[O:8][CH2:7][C:4]1([F:21])[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 2773573(Oxan-4-yl)methanolHCID 47300225-Bromo-6-chloropyridine-3-sulfonamideHCID 167824874-Fluoro-3-nitrobenzenesulfonamide

Product 1

HCID 671264525-bromo-6-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)pyridine-3-sulfonamide

Procedure

The title compound was prepared by substituting (4-fluorotetrahydro-2H-pyran-4-yl)methanol for (tetrahydro-2H-pyran-4-yl)methanol and 5-bromo-6-chloropyridine-3-sulfonamide for 4-fluoro-3-nitrobenzenesulfonamide in EXAMPLE 24A.

Sources & evidence

ORD record
ord-3133bf26bb2c4420a2274e10c29d6f31
Source dataset
uspto-grants-2015_11
Patent number
US09174982B2

Reaction notes

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