4-Aminomethyltetrahydropyran → 5-nitro-6-((tetrahydro-2H-pyran-4-yl)methylamino)pyridine-3-sulfonamide

HRID 707047Notes

Reaction equation

F[C:2]1C=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[O:15]1[CH2:20][CH2:19][CH:18]([CH2:21][NH2:22])[CH2:17][CH2:16]1.FC1(C[NH2:31])CCOCC1>>[N+:12]([C:3]1[CH:4]=[C:5]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:6]=[N:31][C:2]=1[NH:22][CH2:21][CH:18]1[CH2:19][CH2:20][O:15][CH2:16][CH2:17]1)([O-:14])=[O:13]

Participants

Reactant 3

HCID 27732104-Aminomethyltetrahydropyran

HCID 167824874-Fluoro-3-nitrobenzenesulfonamide

HCID 46856407(4-fluorotetrahydro-2H-pyran-4-yl)methanamine

Product 1

HCID 671268595-nitro-6-((tetrahydro-2H-pyran-4-yl)methylamino)pyridine-3-sulfonamide

Procedure

The title compound was prepared by substituting EXAMPLE 364D for 4-fluoro-3-nitrobenzenesulfonamide and (tetrahydro-2H-pyran-4-yl)methanamine for (4-fluorotetrahydro-2H-pyran-4-yl)methanamine in EXAMPLE 138D.

Sources & evidence

ORD record: ord-3a984a2caa2a4cfd9776484bce4e18e1
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09174982B2

Reaction notes

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