4-(Dimethylamino)phenyl isocyanate → HCID 44516007, compound

HRID 707095Notes

Reaction equation

HRID 707095 reaction equation
[N:1]1([C:7]2[N:12]=[C:11]([O:13][CH:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[N:10]=[C:9]([C:20]3[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=3)[N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:27][N:28]([C:30]1[CH:35]=[CH:34][C:33]([N:36]=[C:37]=[O:38])=[CH:32][CH:31]=1)[CH3:29]>>[CH3:27][N:28]([CH3:29])[C:30]1[CH:35]=[CH:34][C:33]([NH:36][C:37]([NH:24][C:23]2[CH:25]=[CH:26][C:20]([C:9]3[N:8]=[C:7]([N:1]4[CH2:2][CH2:3][O:4][CH2:5][CH2:6]4)[N:12]=[C:11]([O:13][CH:14]4[CH2:15][CH2:16][O:17][CH2:18][CH2:19]4)[N:10]=3)=[CH:21][CH:22]=2)=[O:38])=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 27333724-(Dimethylamino)phenyl isocyanateHCID 670218024-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)-1,3,5-triazin-2-yl]aniline

Product 1

HCID 44516007HCID 44516007, compound

Procedure

1-[4-(dimethylamino)phenyl]-3-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)-1,3,5-triazin-2-yl]phenyl}urea was prepared by reacting the 4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)-1,3,5-triazin-2-yl]aniline and the corresponding 4-(N,N-dimethylamino)phenylisocyanate. Product was purified by Gilson, HPLC. MS (ESI) m/z 519.61.

Workup

  1. customProduct was purified by Gilson, HPLC

Sources & evidence

ORD record
ord-f49577c388594c29be743d17e1d9592d
Source dataset
uspto-grants-2015_11
Patent number
US09174963B2

Reaction notes

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