HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | HCID 130403997 | HCID 130403997 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 44548794 | HCID 44548794 | — |
Reaction Steps
1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(piperazin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea-2TFA (230 mg) in dichloromethane (4 mL) and triethylamine (1 mL) was treated with acetyl chloride. The mixture was concentrated to dryness and purified on HPLC to give the title compound as its TFA salt; MS (ES+) 530.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09174963B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-e254ab06a3a44c00959dd607db0636dc |
| Source note | uspto-grants-2015_11 |