Trifluoroacetic acid → 3-Cyclopropyl-6-[[4-(cyclopropylsulfonyl)phenyl](2,4-di fluorophenoxy)methyl]pyridin-2(1H)-one

Participants

Reaction Steps

Trifluoroacetic acid (50 mg) was added to a solution of 3-cyclopropyl-6-{[4-(cyclopropylsulfonyl)phenyl](2,4-difluorophenoxy)methyl}-2-[(4-methoxybenzyl)oxy]pyridine (90 mg) in chloroform (5 mL), and the mixture was stirred at room temperature for two hours. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=88:12→0:100) to give the title compound as a yellow powder (53 mg, 74%).

Provenance & Evidence