phenyl N-(3-carbamoylphenyl)carbamate → 3-({[4-(4-{4-[(Methylcarbamoyl)amino]phenyl}-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide

HRID 707173Notes

Reaction equation

HRID 707173 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)[N:11]=[C:10]([C:20]3[CH:25]=[CH:24][C:23]([NH:26][C:27]([NH:29][CH3:30])=[O:28])=[CH:22][CH:21]=3)[N:9]=2)=[CH:4][CH:3]=1.[C:31]([C:34]1[CH:35]=[C:36]([NH:40][C:41](=[O:49])OC2C=CC=CC=2)[CH:37]=[CH:38][CH:39]=1)(=[O:33])[NH2:32]>>[CH3:30][NH:29][C:27]([NH:26][C:23]1[CH:22]=[CH:21][C:20]([C:10]2[N:11]=[C:12]([N:14]3[CH2:15][CH2:16][O:17][CH2:18][CH2:19]3)[N:13]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([NH:1][C:41]([NH:40][C:36]4[CH:35]=[C:34]([CH:39]=[CH:38][CH:37]=4)[C:31]([NH2:32])=[O:33])=[O:49])=[CH:7][CH:6]=3)[N:9]=2)=[CH:25][CH:24]=1)=[O:28]

Participants

3

Reactant 2

HCID 60630270phenyl N-(3-carbamoylphenyl)carbamateHCID 674385231-(4-(4-(4-Aminophenyl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea

Product 1

HCID 665857873-({[4-(4-{4-[(Methylcarbamoyl)amino]phenyl}-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamideYield 4%

Procedure

The title compound was prepared by following the procedure of example 462 step 7 using 1-(4-(4-(4-aminophenyl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-methylurea and phenyl 3-carbamoylphenylcarbamate. Yield 51 mg, 4% yield.

Sources & evidence

ORD record
ord-6c6f28adf25844e5a168649f59ba857b
Source dataset
uspto-grants-2015_11
Patent number
US09174963B2

Reaction notes

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