反应详情

(2-amino-4-chlorophenyl)methanol (10.08 g, 64.0 mmol) was suspended in chloroform (250 mL) and treated with manganese dioxide (15.87 g, 183 mmol). The mixture was stirred vigorously and heated at reflux. The oxidation was followed by TLC and found to be complete after 1 hour. The suspension was filtered through a pad of CELITE™ and evaporated to dryness under reduced pressure. Further drying under high vacuum gave a dark red solid which was used in the next step without further purification.

1. temperatureheated
2. temperatureat reflux
3. filtrationThe suspension was filtered through a pad of CELITE™
4. customevaporated to dryness under reduced pressure
5. customFurther drying under high vacuum
6. customgave a dark red solid which
7. customwas used in the next step without further purification