2-Chloronicotinic acid → 2-(2-Chloropyridin-3-yl)acetonitrile

HRID 707225Notes

Reaction equation

HRID 707225 reaction equation
[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=O.ClC1[N:20]=[CH:19]C(F)=CC=1C(O)=O>>[Cl:1][C:2]1[C:3]([CH2:4][C:19]#[N:20])=[CH:7][CH:8]=[CH:9][N:10]=1

Participants

3

Reactant 2

HCID 762582-Chloronicotinic acidHCID 114352432-Chloro-5-fluoronicotinic acid

Product 1

HCID 147395432-(2-Chloropyridin-3-yl)acetonitrile

Procedure

(2-Chloropyridin-3-yl)acetonitrile was synthesized analogous to intermediate 13 using 2-chloronicotinic acid as a starting material in place of 2-chloro-5-fluoronicotinic acid.

Sources & evidence

ORD record
ord-2aa605e6fe674ab79c9311eedc98bdcb
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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