2-(2-Chloropyridin-3-yl)acetonitrile → HCID 86694107, compound

HRID 707227Notes

Reaction equation

HRID 707227 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[CH:6][C:5](F)=[CH:4][N:3]=1.ClC1C(CC#N)=CC=CN=1.ClC1C(CC#N)=CC(F)=CN=1>>[Cl:1][C:2]1[C:7]([C:8]2([C:11]#[N:12])[CH2:9][CH2:10]2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 147395432-(2-Chloropyridin-3-yl)acetonitrileHCID 86694105HCID 86694105, compound2×HCID 86694106HCID 86694106, compound

Product 1

HCID 86694107HCID 86694107, compound

Procedure

1-(2-Chloropyridin-3-yl)cyclopropanecarbonitrile was synthesized analogous to 1-(2-chloro-5-fluoropyridin-3-yl)cyclopropanecarbonitrile (Intermediate 15) using (2-chloropyridin-3-yl)acetonitrile as a reactant in place of 2-(2-chloro-5-fluoropyridin-3-yl)acetonitrile.

Sources & evidence

ORD record
ord-0d2b0d2244b341859f0aaf0de9309131
Source dataset
uspto-grants-2015_11
Patent number
US09174992B2

Reaction notes

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