4-Toluenesulfonyl chloride → HCID 178427793, compound

Participants

Reaction Steps

A solution of benzyl (cis-3-hydroxycyclobutyl)carbamate (intermediate 47, 0.3 g, 1.356 mmol), p-toluenesulfonyl chloride (0.284 g, 1.492 mmol), and triethylamine (0.567 ml, 4.07 mmol) in dichloromethane (2.71 ml) was stirred at room temperature for 14 hours. The mixture was diluted with dichloromethane and washed with saturated sodium bicarbonate solution. The organic layer was dried over sodium sulfate, rotovapped, and advanced to next step directly.

Provenance & Evidence