2-Chlorobenzothiazole → HCID 86694198, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-nitro-N-(piperidin-4-yl)pyridine-2-amine hydrochloride (intermediate 58, 500 mg, 2.24 mmol) and 2-chloro-benzo[d]thiazole (379 mg, 2.24 mmol) in N-methylpyrrolidine (5 mL) was heated at 180° C. in microwave for 2 hours. The mixture was diluted with water (60 mL) and extracted with ethyl acetate (2×50 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. Purification by silica chromatography gave N-(1-(benzo[d]thiazol-2-yl)piperidin-4-yl)-3-nitropyridin-2-amine (270 mg, 0.76 mmol, 33.8% yield).

Provenance & Evidence