Propionic Acid → HCID 86694200, compound

Participants

Reaction Conditions

Reaction Steps

N1-(1-(Benzo[d]thiazol-2-yl)piperidin-4-yl)pyridine-2,3-diamine (200 mg, 0.61 mmol) was combined with tetramethylorthocarbonate (2 mL) and propionic acid (8 mg) and heated at 90° C. for 2 hours. After that, the reaction solution was concentrated under reduced pressure and the residue was purified by silica chromatography to give 2-(4-(2-methoxy-3H-imidazo[4,5-b]pyridine-3-yl)piperidin-1-yl)benzo[d]thiazole (30 mg, 0.082 mmol, 13.4% yield). M+1: 366.

Provenance & Evidence