3-(benzylamino)-N-methoxy-N-methylcyclobutanecarboxamide → 3-amino-N-methoxy-N-methylcyclobutanecarboxamide

Participants

Reaction Steps

A mixture of 3-(benzylamino)-N-methoxy-N-methylcyclobutanecarboxamide (349 mg, 2.2 mmol) and wet palladium hydroxide on activated carbon (50 wt %, 200 mg) in methanol (30 mL) was stirred under hydrogen (30 psi) at room temperature for 13 hours then the reaction mixture was filtered through CELITE™ H and washed with methanol. The filtrate was concentrated in vacuo to give 3-amino-N-methoxy-N-methylcyclobutanecarboxamide (332 mg, 2.09 mmol, yield 95%).

Provenance & Evidence