反应详情

4-(2-Phenyl-tetrahydro-pyran-2-yl)-phenol (500 mg, 2 mmol) was dissolved in pyridine (10 mL). Acetic anhydride (1 mL) was added at drop wise at 0° C. The reaction temperature was allowed to raise to room temperature. After 1 h the reaction was quenched the addition of water (5 mL). Dichloromethane (20 mL) was added. The organic phase was washed with aqueous HCl (1M, 2×10 mL), brine (10 mL), dried (Na2SO4) and concentrated in vacuo. Purified on a short column (eluent: dichloromethane). Yield: 560 mg.

1. customAfter 1 h the reaction was quenched
2. additionthe addition of water (5 mL)
3. additionDichloromethane (20 mL) was added
4. washThe organic phase was washed with aqueous HCl (1M, 2×10 mL), brine (10 mL)
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in vacuo
7. customPurified on a short column (eluent: dichloromethane)