4-Toluenesulfonyl chloride → HCID 178427793, compound

Participants

Reaction Steps

A solution of Intermediate 47 (0.67 g, 3.03 mmol), p-toluenesulfonyl chloride (Sigma Aldrich, 1.155 g, 6.06 mmol), triethylamine (Aldrich, 1.688 ml. 12.11 mmol) in DCM (6.06 ml) was stirred at room temperature overnight. Reaction mixture was diluted with DCM and washed with saturated NaHCO3 solution. Organic layer was dried over sodium sulfate to provide 1.4 g crude product upon rotovap. Material was advanced to next step before further purification.

Provenance & Evidence