反应详情

To a round bottomed flask was added tert-butyl(cis-3-(7,7-dimethyl-6-oxo-6,7-dihydro-5H-pyrrolo[2,3-b]pyrazin-5-yl)cyclobutyl)carbamate (0.1812 g, 0.545 mmol) and hydrogen chloride, 4.0M solution in 1,4-dioxane (0.136 ml, 0.545 mmol, Sigma-Aldrich Chemical Company, Inc.) to stir at room temperature for 1 h. Solvent was evaporated and carried on without further purification. LCMS showed product peak at 0.357 min (m+=233.0). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.33 (s, 5 H) 2.61-2.74 (m, 2 H) 2.91-3.04 (m, 2 H) 3.63-3.76 (m, 1 H) 4.50-4.64 (m, 1 H) 8.18 (s, 2 H)

1. customSolvent was evaporated
2. customcarried on without further purification
3. customat 0.357 min