Potassium peroxymonosulphate → HCID 71539176, compound

Participants

Reaction Steps

(S)-1-(4-(4-(5-fluoro-2-(methylthio)phenyl)-6-(3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-methylurea (258 mg, 0.55 mmol) was stirred with Potassium peroxymonosulfate (Oxone) (1.01 g, 1.65 mmol) in THF:MeOH:H2O (5:3:2)(10 ml) for 1 hour at 0° C. Reaction allowed to reach room temperature and stirred overnight with more oxone (1.01 g, 1.65 mmol). The mixture is quenched with saturated sodium thiosulfate solution (10 ml). Diluted with DCM (50 mL) and washed with brine (50 mL). The organic layer was passed through a hydrophobic frit and concentrated in vacuo. The resulting solid was purified by prep HPLC at to afford the title compound as a yellow solid. (127 mg, Yield 46%)

Provenance & Evidence