(2R)-4-(1-(Diphenylmethyl)azetidin-3-yl)-1,2-dimethylpiperazine → (R)-4-(Azetidin-3-YL)-1,2-dimethylpiperazine

Participants

Reaction Steps

To a mixed solution of (2R)-4-(1-(diphenylmethyl)azetidin-3-yl)-1,2-dimethylpiperazine (342 mg, 1.02 mmol) described in Production Example 5-2 and methanol (10 mL) was added palladium hydroxide-carbon (200 mg) at room temperature. The resultant mixture was stirred under a hydrogen atmosphere at room temperature and at 0.35 MPa to 0.40 MPa for 5 hours. The reaction mixture was purged with a nitrogen atmosphere, and then filtrated using Celite. A filtrate was concentrated under a reduced pressure to give a mixture (287 mg) of the title compound and benzylbenzene. The product was used in the subsequent reaction without further purification.

Provenance & Evidence