(2S)-1-(1-(Diphenylmethyl)azetidin-3-yl)-2,4-dimethylpiperazine → (2S)-1-(azetidin-3-yl)-2,4-dimethylpiperazine

Participants

Reaction Steps

To a mixed solution of (2S)-1-(1-(diphenylmethyl)azetidin-3-yl)-2,4-dimethylpiperazine (321 mg, 0.957 mmol) described in Production Example 6-2 and methanol (7.0 mL) was added palladium hydroxide-carbon (150 mg) at room temperature. The resultant mixture was stirred under a hydrogen atmosphere at room temperature and at 0.35 MPa to 0.40 MPa for 5 hours. The reaction mixture was purged with a nitrogen atmosphere and then filtrated using Celite. A filtrate was concentrated under a reduced pressure to give a mixture (263 mg) of the title compound and benzylbenzene. The product was used in the subsequent reaction without further purification.

Provenance & Evidence