HCID 118162414, compound → HCID 118162540, compound

HRID 707526Notes

Reaction equation

HRID 707526 reaction equation
C([O:3][CH:4](OCC)[C:5]1[N:10]=[C:9]([N:11]2[CH2:14][CH:13]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[C@H:17]([CH3:22])[CH2:16]3)[CH2:12]2)[C:8]([F:23])=[CH:7][CH:6]=1)C>C(O)=O>[CH3:22][C@H:17]1[N:18]([CH3:21])[CH2:19][CH2:20][N:15]([CH:13]2[CH2:12][N:11]([C:9]3[N:10]=[C:5]([CH:4]=[O:3])[CH:6]=[CH:7][C:8]=3[F:23])[CH2:14]2)[CH2:16]1

Participants

3

Reactant 1

HCID 118162414HCID 118162414, compound

Product 1

HCID 118162540HCID 118162540, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

To (2R)-4-(1-(6-(diethoxymethyl)-3-fluoropyridin-2-yl)azetidin-3-yl)-1,2-dimethylpiperazine (157 mg, 0.428 mmol) described in Production Example 24-1-2 was added formic acid (5.00 mL) at room temperature. The resultant mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under a reduced pressure, to give a crude product (125 mg) of the title compound. The product was used in the subsequent reaction without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated under a reduced pressure

Sources & evidence

ORD record
ord-b8158bb07807462590ee995322b2edc9
Source dataset
uspto-grants-2015_11
Patent number
US09174998B2

Reaction notes

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