Triacetoxyperiodinane → HCID 118162456, compound

Participants

Reaction Steps

To a mixed solution of (6-(3-(4-(dimethylamino)piperidin-1-yl)azetidin-1-yl)-5-fluoropyridin-2-yl)methanol (240 mg, 0.779 mmol) described in Production Example 25-3 and dichloromethane (6.00 mL) was added Dess-Martin periodinane (400 mg) at 0° C. The resultant mixture was stirred for 1.5 hours. Quenched with an aqueous sodium hydrogen carbonate solution and sodium thiosulfate, and the reaction solution was extracted with chloroform. An organic layer was dried over sodium sulfate and then filtrated, and the solvent was then evaporated under a reduced pressure to give the title compound (320 mg). The product was used in the subsequent reaction without further purification.

Provenance & Evidence