反应详情

温度

30 °C

To a mixture of 2-(5-ethoxycarbonyl-isoxazol-3-yl)-pyridine (6.5 gm), in ethanol (80 ml) was added sodium borohydride (2 gm) in lots at 30° C. It was stirred at 30° C. over a period of 1.5 h. The reaction was monitored by TLC. Upon consumption of starting material, aqueous ammonium chloride solution was added. The mixture was extracted with ethyl acetate. Combined organic layers was washed with water and concentrated under vacuum to provide title compound in 7.7 gm quantity. It was purified by using silica gel column chromatography to afford tile compound in 4.5 g (85%) quantity as off-white solid.

1. customUpon consumption of starting material, aqueous ammonium chloride solution
2. additionwas added
3. extractionThe mixture was extracted with ethyl acetate
4. washCombined organic layers was washed with water
5. concentrationconcentrated under vacuum