Ethanol → HCID 67958818, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(3-ethoxycarbonyl-isoxazol-5-yl)-pyrimidine (35 gm) in 2:1 v/v ethanol:THF mixture (525 ml) was added sodium borohydride (7.5 gm) in lots at 0° C. It was stirred at 30° C. temperature over a period of 4 h. The reaction mixture was evaporated under vacuum to provide a residue and to the residue, (150 ml) was added. The suspension was extracted with ethyl acetate (4.5 ltr). Combined organic layers was washed with water and concentrated under vacuum to provide crude mass in 23 gm quantity, which was recrystallized from ethanol to provide the title compound in 15.1 gm quantity (53%) as pale yellow solid.

Provenance & Evidence