Benzoyl Peroxide → HCID 67958922, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-methyl-5-isoxazol-3-yl-pyrimidine (30 gm), N-bromosuccinamide (49.8 gm), and 98% benzoyl peroxide (13.54 gm) in carbon tetrachloride (1200 ml) was heated to 75° C. temperature. The reaction mixture was stirred at 75° C. for 24 h. The reaction mixture was filtered under suction at 25° C. to 35° C. temperature. The solid was washed with carbon tetrachloride (400 ml). The filtrate was washed with saturated aqueous sodium bicarbonate solution (400 ml×2) and evaporated under vacuum to provide a crude material (52 gm) which upon silica gel column chromatography afforded desired compound in 14 gm quantity (40%), dibromo compound in 16.8 gm and starting material 6.5 gm quantities.

Provenance & Evidence