反应详情

温度

30 °C

To a mixture of (RS)-2-(5-(1-hydroxy-ethyl)-isoxazol-3-yl)-pyridine (0.9 gm), and triphenylphosphene (1.77 gm) in dichloromethane (20 ml) was added carbontetrabromide (6 gm) at 0° C. The reaction mixture was stirred at 30° C. over a period of 2.5 h. The reaction was monitored by TLC. The reaction was quenched by addition of water and layers were separated. Combined organic extract was washed with brine and evaporated under vacuum to provide the 1.7 gm crude mass which was purified by using silica gel column chromatography to provide title compound in 0.8 gm quantity (65%).

1. customThe reaction was quenched by addition of water and layers
2. customwere separated
3. extractionCombined organic extract
4. washwas washed with brine
5. customevaporated under vacuum
6. customto provide the 1.7 gm crude mass which
7. customwas purified