Water → HCID 67958915, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(3-(1-oxo-ethyl)-isoxazol-5-yl)-pyrimidine (1.2 gm) in methanol (20 ml) was added sodium borohydride (0.485 gm) in lots at 0° C. It was stirred at 30° C. over a period of 2 h. The reaction mixture was evaporated under vacuum to provide a residue. The residue was stirred with water and extracted with ethyl acetate (25 ml X3). Combined organic layers was washed with aqueous sodium bicarbonate solution followed by water and concentrated under vacuum to provide title compound in 1.1 gm quantity (91%). It as used as without purification for the next reaction.

Provenance & Evidence