HCID 68758033, compound → HCID 67960495, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-(5-ethoxycarbonyl-1,3,4-thiadiazol-2-yl)-pyridine (2 gm) in THF (40 ml) was added methyl magnesium iodide (15 ml, 1.4 M solution in THF) at −40° C. over a period of 15 minutes. The reaction mixture was stirred for 2 h at −40° C. It was quenched by addition of aqueous ammonium chloride solution (20 gm) and stirred at 0° C. over a period of 10 minutes. It was extracted with ethyl acetate (100 ml×2). Combined organic layers was washed with water and evaporated under vacuum to provide a title compound in 1.5 gm quantity (86%) as off white solid.

Provenance & Evidence