Sodium borohydride → HCID 67960301, compound

Participants

Reaction Steps

To a mixture of 2-[5-(1-oxo-ethyl)-1,3,4-thiadiazol-2-yl]-pyridine (1.5 gm), in methanol (25 ml) was added sodium borohydride (0.2 gm) in lots at 30° C. It was stirred over a period of 2 h. The reaction was monitored by TLC. Solvent was evaporated under vacuum and water (20 ml) was added. The mixture was extracted with ethyl acetate (100 ml×2). Combined organic layers was washed with water and concentrated under vacuum to provide title compound in 1.0 gm quantity (67%). It as used as without purification for the next reaction.

Provenance & Evidence