Triethylamine → HCID 86706843, compound

Participants

Reaction Steps

To a mixture of (RS)-2-(5-(1-hydroxy-ethyl)-1,3,4-thiadiazol-2-yl)-pyridine (1.0 gm), and triethylamine (2 ml) in dichloromethane (50 ml) was added methanesulfonyl chloride (0.9 gm) at −10° C. The reaction mixture was stirred over a period of 1 h. The reaction was quenched by addition of water and layers were separated. Aqueous layer was extracted with dichloromethane. Combined organic layer was washed with aqueous sodium bicarbonate followed by water and evaporated under vacuum to provide the title compound in 1.0 gm quantity (73%) as an oil.

Provenance & Evidence