Lithium Bromide → HCID 67960441, compound

Participants

Reaction Steps

A mixture of (RS)-2-[5-(1-methanesulfonyloxy-ethyl)-1,3,4-thiadiazol-2-yl]-pyridine (1.0 gm), lithium bromide (0.5 gm) in acetone (20 ml) was stirred at reflux over a period of 1 h. The reaction mixture was evaporated under vacuum to provide a crude mass. Crude mass was stirred with ice cold water and extracted with dichloromethane (50 ml×2). The combined organic layer was evaporated under vacuum to afford the title compound in 0.8 gm quantity (85%) as oil.

Provenance & Evidence