HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 4-(Hydroxymethyl)piperidine-4-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 1-Boc-4-cyano-4-(hydroxymethyl)piperidine | HCID 22248607 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(Hydroxymethyl)piperidine-4-carbonitrile hydrochloride | HCID 86677054 | — |
Reaction Steps
4 M hydrochloric acid/dioxane solution (15 ml) was added to a solution of tert-butyl 4-cyano-4-(hydroxymethyl)piperidine-1-carboxylate (886 mg) in dioxane (5 ml), and stirring was performed for one hour at room temperature. The reaction mixture was concentrated under reduced pressure, and 4-(hydroxymethyl)piperidine-4-carbonitrile hydrochloride (663 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822688B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-af9ebdb15f504c56a5e945f04901d62c |
| Source note | uspto-grants-2014_09 |