反应详情

4M hydrochloric acid/dioxane solution (11.4 ml) was added to tert-butyl rel-(3R,4S)-3-fluoro-4-(hydroxymethyl)-4-methoxypiperidine-1-carboxylate (800 mg) and stirring was performed at room temperature for 1 hour. Concentration under reduced pressure gave rel-[(3R,4S)-3-fluoro-4-methoxypiperidin-4-yl]methanol hydrochloride (606 mg).

1. concentrationConcentration under reduced pressure