HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 71268660, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Chloride | HCID 7503 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Methyl-piperidine-4-carboxylic acid aMide hydrochloride | HCID 67506369 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 71268660 | HCID 71268660 | 97.8% |
Reaction Steps
Benzyl chloride (1.90 g) and sodium carbonate (1.59 g) were added to a DMF (70 ml) suspension of 4-methylpiperidine-4-carboxamide hydrochloride (2.24 g), and stirring was performed at room temperature for 16 hours. After adding water to the reaction liquid, extraction was performed with EtOAc. The organic layer was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (MeOH/chloroform) to obtain 1-benzyl-4-methylpiperidine-4-carboxamide (2.85 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822688B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7dc46dc1d2794a90b2f0c8c24f019f0b |
| Source note | uspto-grants-2014_09 |