piperidin-4-yl(pyrrolidin-1-yl)methanone → HCID 58204132, compound

HRID 707956Notes

Reaction equation

HRID 707956 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[NH:23]1[CH2:28][CH2:27][CH:26]([C:29]([N:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)=[O:30])[CH2:25][CH2:24]1>>[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([N:23]5[CH2:24][CH2:25][CH:26]([C:29]([N:31]6[CH2:35][CH2:34][CH2:33][CH2:32]6)=[O:30])[CH2:27][CH2:28]5)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 1520212piperidin-4-yl(pyrrolidin-1-yl)methanoneHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58204132HCID 58204132, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with piperidin-4-yl(pyrrolidin-1-yl)methanone (1.2 equiv) to give 206 (M+1 478.0)

Sources & evidence

ORD record
ord-157d139f2c674680b35304713a73cb29
Source dataset
uspto-grants-2015_11
Patent number
US09175009B2

Reaction notes

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