HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-((Methylamino)acetyl)morpholine → 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid methyl-(2-morpholin-4-yl-2-oxo-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-((Methylamino)acetyl)morpholine | HCID 2517683 | — |
| Reactant | 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid | HCID 58203883 | — |
| Product | 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid methyl-(2-morpholin-4-yl-2-oxo-ethyl)-amide | HCID 58204224 | — |
Reaction Steps
Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and 2-(methylamino)-1-morpholinoethanone to give 225. MS: (ESI+)=454.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09175009B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-9b97313e92814688a603a553cf2df497 |
| Source note | uspto-grants-2015_11 |