3,5-Dimethylisoxazole-4-boronic acid pinacol ester → HCID 58204196, compound

HRID 708036Notes

Reaction equation

HRID 708036 reaction equation
[OH:1][CH2:2][CH2:3][N:4]([CH:22]([CH3:24])[CH3:23])[C:5]([C:7]1[S:8][C:9]2[CH2:10][CH2:11][O:12][C:13]3[CH:20]=[C:19](Br)[CH:18]=[CH:17][C:14]=3[C:15]=2[N:16]=1)=[O:6].[CH3:25][C:26]1[C:30](B2OC(C)(C)C(C)(C)O2)=[C:29]([CH3:40])[O:28][N:27]=1>>[OH:1][CH2:2][CH2:3][N:4]([CH:22]([CH3:24])[CH3:23])[C:5]([C:7]1[S:8][C:9]2[CH2:10][CH2:11][O:12][C:13]3[CH:20]=[C:19]([C:30]4[C:26]([CH3:25])=[N:27][O:28][C:29]=4[CH3:40])[CH:18]=[CH:17][C:14]=3[C:15]=2[N:16]=1)=[O:6]

Participants

3

Reactant 2

HCID 27586563,5-Dimethylisoxazole-4-boronic acid pinacol esterHCID 670506018-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (2-hydroxyethyl)-isopropylamide

Product 1

HCID 58204196HCID 58204196, compound

Procedure

Following Example 267, 8-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (2-hydroxyethyl)-isopropylamide and 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole to give 291. MS: (ESI+)=428.1

Sources & evidence

ORD record
ord-413883b9eb3c47c68d0b0496f2ec494d
Source dataset
uspto-grants-2015_11
Patent number
US09175009B2

Reaction notes

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