Diisopropylethylamine → HCID 58203818, compound

Participants

Reaction Steps

Following the procedure for 395, 8-azetidin-3-yl-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene free base 235, diisopropylethylamine and isopropylsulfonyl chloride were reacted. The reaction mixture was loaded directly onto a silica column with no aqueous work-up to give 321 isolated as a solid (57 mg, 25%). LCMS: RT=12.20 min, [M+H]+=474. 1H NMR δ (ppm) (CDCl3): 8.39 (1H, d, J=8.20 Hz), 7.93 (1H, s), 7.21 (1H, dd, J=8.21, 1.89 Hz), 7.06 (1H, d, J=1.84 Hz), 5.96-5.88 (1H, m), 4.42 (2H, t, J=5.00 Hz), 4.29 (2H, t, J=8.23 Hz), 4.15 (2H, t, J=7.30 Hz), 3.84-3.78 (1H, m), 3.43 (2H, t, J=5.03 Hz), 3.16 (1H, t, J=6.84 Hz), 1.64 (6H, d, J=6.62 Hz), 1.40 (6H, d, J=6.84 Hz)

Provenance & Evidence