L-Lactic Acid → HCID 58204115, compound

Participants

Reaction Steps

Following the procedure for 318, 8-azetidin-3-yl-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene free base 235 and L-(+)-lactic acid were reacted to give 323 isolated as an off-white solid after freeze-drying (42 mg, 29%). LCMS: RT=10.71 min, [M+H]+=440. 1H NMR δ (ppm) (CDCl3): 8.40-8.33 (1H, m), 7.90 (1H, s), 7.10 (1H, t, J=6.16 Hz), 6.99 (1H, d, J=8.83 Hz), 5.91-5.83 (1H, m), 4.62-4.36 (5H, m), 4.21 (3H, m), 4.18-4.08 (1H, m), 3.93-3.84 (1H, m), 3.40 (2H, t, J=5.01 Hz), 1.61 (6H, d, J=6.62 Hz), 1.34 (3H, d, J=6.57 Hz)

Provenance & Evidence