反应详情

A mixture of 0.67 g (5.0 mmol) of 1-(1-hydroxy-2-methylpropan-2-yl)thiourea and 1.60 g (5.00 mmol) of 4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one in 30 ml of ethanol was heated under reflux for 3 hours. The mixture was concentrated, the residue purified on silica gel column eluting the product with 10% of methanol in dichloromethane. Yield 1.38 g (75%). MS(ESI+): 369.3

1. temperaturewas heated
2. temperatureunder reflux for 3 hours
3. concentrationThe mixture was concentrated
4. customthe residue purified on silica gel column
5. washeluting the product with 10% of methanol in dichloromethane