HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,8-dibromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one → N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,8-dibromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one | HCID 57900275 | — |
| Reactant | 1-(2-Methyl-1-(tritylamino)propan-2-yl)thiourea | HCID 87249918 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide | HCID 86652327 | 68% |
Reaction Steps
Following the Example 356, 1-(2-methyl-1-(tritylamino)propan-2-yl)thiourea was reacted with 4,8-dibromo-3,4-dihydro-2Hbenzo[b]oxepin-5-one in ethanol under reflux for 18 hours to give N2-(8-bromo-4,5-dihydrothiazolo[4,5-d]benzo[b]oxepin-2-yl)-2-methylpropane-1,2-diamine hydrobromide. Yield 68%. MS(ESI+): 368.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09175009B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-5c69a58c257840859d1bcbf923c19648 |
| Source note | uspto-grants-2015_11 |