Triethylamine → HCID 58203757, compound

Participants

Reaction Steps

Following the procedure for 394, 8-azetidin-3-yl-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene TFA salt 235, 2-chloroethanesulfonyl chloride, and 1.0 equivalents of triethylamine were reacted to give 445. LCMS: RT=8.49 min, [M+H]+=476. 1H NMR δ (ppm) (DMSO-d6): 8.29 (1H, d, J=8.20 Hz), 8.06-8.03 (1H, m), 7.22 (1H, dd, J=8.27, 1.86 Hz), 7.13 (1H, d, J=1.82 Hz), 5.82-5.72 (1H, m), 4.36-4.26 (4H, m), 4.10-3.94 (3H, m), 3.45-3.35 (4H, m), 2.72-2.65 (2H, m), 1.50 (6H, d, J=6.59 Hz). 1 Exchangeable proton not seen

Provenance & Evidence