Morpholine, 4-(chloroacetyl)- → HCID 58204234, compound

Participants

Reaction Steps

Following the procedure of 319, a suspension of 8-azetidin-3-yl-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene TFA salt 235 (200 mg, 0.42 mmol) and 4-(2-chloroacetyl)morpholine gave 471 isolated as a yellow solid (79 mg, 22%). LCMS: RT=3.17 min, [M+H]+=495. 1H NMR δ (ppm) (DMSO-d6): 8.25 (1H, d, J=8.17 Hz), 8.05 (1H, s), 7.17 (1H, dd, J=8.24, 1.82 Hz), 7.03 (1H, d, J=1.77 Hz), 5.82-5.73 (1H, m), 4.35-4.29 (2H, m), 3.67-3.56 (2H, m), 3.58-3.45 (5H, m), 3.44-3.34 (6H, m), 3.31 (2H, s), 3.16 (2H, t, J=6.11 Hz), 1.50 (6H, d, J=6.59 Hz)

Provenance & Evidence